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Since 1994, we have been providing innovative diagnostic services in clinical genetics, applying our research in fetal medicine and reproductive biology globally . . .
Reproductive Immunology
Lymphocytes NK cells (CD3-CD56+/CD16+)
In cases of suspected infertility and in women with a clinical history of recurrent miscarriages, we suggest proceeding with a further investigation consisting of an immunological investigation, in search of Natural Killer cells, which once identified are typed, since their expression with particular receptors seems to be associated with a
immune dysregulation that inhibits embryonic implantation
What are Natural Killer Cells?
Natural Killer (NK) cells are a type of lymphocytes that are part of the immune system and play a crucial role in identifying cells with morpho-structural abnormalities as in the case of tumor cells and virus-infected cells.
In the context of fertility, in addition to their defensive function, during pregnancy, for example, NK cells contribute to the regulation of the immune response through the secretion of cytokines. This immunoregulatory mechanism can lead to an excessive response that, recognizing the embryo as foreign, causes recurrent miscarriages.
This type of infertility is known as alloimmune infertility, as it results from the rejection of the embryo by the mother's body.
In the decidua, in fact, there are 3 subpopulations of NK cells, including dNK1, which receive imprinting from placental cells, thus improving their response to placental implantation in the phases following fetal implantation.
Although these alterations can occur in apparently healthy women, without any clinical manifestations, alloimmune infertility has a higher risk of manifesting itself in women suffering from other disorders.
of the immune system, including:
Systemic lupus erythematosus (SLE)
Rheumatoid arthritis.
Vasculitis
Hashimoto's thyroiditis
Lymphocyte and Plasma Cell Tests:
NK (CD3-/CD56+CD16+)
LGL-T CD3-/CD56+CD16+)
It is performed by the IRG through blood sampling or hysteroscopy on site and remotely
