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Since 1994, we've been providing innovative diagnostic services in clinical genetics, applying our research in fetal medicine and reproductive biology internationally
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Immunology of infertility
KIR HLAC test :
What is it, when is it needed, and how should it be interpreted?
View KIR HLAC analysis information on IG
What's test KIR HLA-C ?
The analysis of KIR genes and HLA-C polymorphisms currently represents one of the most useful assessments for investigating potential immunological risk factors involved in cases of idiopathic infertility and repeated implantation failure.
"These tests allow us to identify potential unfavorable maternal-fetal combinations, which could contribute to an altered immune response to the embryo, potentially associated with idiopathic infertility and miscarriage in couples."
The role of immunological compatibility between mother and fetus
In maternal-fetal immunological compatibility, it is essential to analyze not only KIR genes but also parental HLACs, since they are transmitted to the blastocyst following Mendelian segregation. This integrated approach allows us to precisely identify the functional interactions between KIR and HLA-C epitopes, which are essential for ensuring optimal embryo implantation.
“Thanks to all this information, it is possible to personalize the diagnostic and therapeutic path, increasing the chances of success in Medically Assisted Reproduction (MAP) treatments, offering targeted support even to couples with natural infertility of unexplained cause.”
What is the KIR HLAC test useful for in PMA (heterologous/homologous):
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Identify causes of miscarriage and idiopathic infertility by studying immunogenetic interactions between mother and embryo;
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Evaluate potential immunological conditions adverse to proper embryo implantation;
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Make more precise clinical decisions, reducing the risk of further reproductive failure, including:
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Determine the optimal number of embryos to transfer
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Choose a compatible donor, in the case of gamete donation
Where can the KIR HLAC exam be taken?
Interpretation by our specialists is a crucial step on the path to parenthood. An in-depth analysis of the couple's medical history, combined with accurate interpretation of genetic tests, allows us to identify the possible causes of reproductive failure and determine the most appropriate treatment.
The test can be performed, with sample shipment both nationally and internationally. Online reports are available within 7 days.
On the path to parenthood, consulting with our specialists is essential, as only through a careful analysis of the couple's medical history and the correct interpretation of genetic tests is it possible to identify the underlying causes of failure and define the most appropriate treatment plan!
Why is it important to perform the KIR HLAC?
in those cases of unknown infertility and recurrent miscarriages?
KIR HLAC - La compatibilità immunologica di coppia per il successo della gravidanza #kirhlac
International Medical Shipping
How to do the KIR HLAC test remotely?
Patients seeking the possibility to carry out genetic tests may fill a form to receive a kit for blood sampling and packaging to deliver by a dedicated transport courier the samples to the laboratory.
This service free of charge may allow to patients from other part of Italy and abroad (international shipment) to undergo immunogenetic tests.
Diagnostic results will be delivered to patient’s mail address within two weeks by the arrival of blood samples to the laboratory. Please fill out the form in the Contact section, or join us to WhatsApp Business profile for more information
